Linear morphea inflammatory myositis

Linear morphea inflammatory myositis. Percent improvement in thickness of skin. M34. Imiquimod 5% cream, applied 3–5 times a week for 24 weeks. Nevertheless, the imaging features of morphea reflect pathomorphologic Feb 13, 2023 · Introduction. Up to 50% of patients concomitantly present plaque morphea, thus having the mixed variant. These cases demonstrate that inflammatory myopathy should be considered in patients with localized scleroderma and Inflammatory cells were often found along the dermal-subcutaneous interface when bottom-heavy and full-thickness sclerosis was present (41/61, 67. Keywords: Inflammatory myopathy; Linear Nov 14, 2023 · Causes. Introduction. Adnexal abnormalities of the lacrimal gland, eyelids, and eyelashes accounted for the majority of ocular findings (41. Morphea is associated with cosmetic and functional sequelae, and internal organ involvement is rare. There are several types of morphea: Localized or circumscribed morphea causes patients to develop oval-shaped areas of redness. Statements. 3). It is a progressive disease of skin and connective tissue (cartilage, bone, fat, and the tissues that support the nerves and blood vessels). While the etiology is Feb 16, 2022 · In contrast to SSc, morphea is less symmetric, better demarcated, and typically spares the hands. Oct 26, 2022 · Morphea can occur anywhere on the body, and often follow three distinct stages defined as (1) an early inflammatory stage, (2) a fibrotic phase, and (3) an inactive or “burnt out” stage. 1 The peak onset is between the ages of 30 and 50 years. In this report, we present the case of a 19-year-old man with linear morphea with inflammatory myositis who presented to our clinic 1 year after symptom onset with severe elbow flexion contracture. Sclerosis and inflammation (defined as presence of mild, moderate to severe inflammation, and any sclerosis [top/bottom heavy or full thickness]) occurred simultaneously in 46. Morphea is an inflammatory, sclerosing skin disorder that can involve the underlying soft tissues. Jul 8, 2019 · Early presence of the pro-inflammatory cytokines IL-2 and IL-6 inducing Th17 in morphea patients suggests that an early increase of Th1 cytokines mediates the active, inflammatory phase of the disease (which was further supported by their later work) , and the subsequent inflammation and transition to the fibrotic damage phase is achieved via Oct 20, 2011 · Abstract. Feb 13, 2023 · 1. Muscle biopsy can confirm the diagnosis of myositis, which if identified, will require anti-inflammatory and/or immunosuppressive therapy. We present a review of the current Jan 5, 2023 · ICD coding. Oct 1, 2013 · Of these patients, 66. Linear Morphea With Inflammatory Myositis. 0 - progressive systemic sclerosis. Linear morphea is thought to be the most common subtype of morphea in children; it is one of the five subtypes of morphea: circumscribed (with superficial and deep variants), linear (with trunk/limb variant and head variant), generalized, pansclerotic, and mixed. Skin patches are generally oval-shaped unless it is linear morphea. (See chap. Generalized morphea is more widespread, affecting a number Three Types of Localized Scleroderma: Localized, Generalized and Linear. 3, 4, 5 Genetic mosaicism has been suggested as a contributing pathogenic mechanism, given the strong correlation of linear morphea with the lines of Blaschko. 2% (42/91). Steroids are effective in the early inflammatory stage and used in combination with methotrexate. Morphea, such as scleroderma, is characterized as a sclerosing skin disorder, due to characteristic histological findings shared by both disorders, including sclerosis of the dermis and sometimes subcutis in the absence of fibroblast proliferation. morphea, is the most common form in adults with peak incidence in the third and fourth decade and is associated with lower morbidity3. It often only affects the outer layer of skin but sometimes leads to more serious issues due to the involvement of deeper parts of the body. There is a periadnexal and perivascular lymphohistiocytic inflammatory infiltrate with fibroblasts, and the periadnexal fat pad disappears or decreases. Morphea is a disorder primarily affecting the skin. scholarly article. instance of. 6 years). Jul 1, 2018 · Abstract. Immune Dermatomyopathies: Muscle Pathology (3 different patterns) Dermatomyositis with Vascular pathology (DM-VP): Common in childhood. Morphea is defined by periods of activity (inflammation and fibrosis) which leads to damage and atrophy. Morphea, also known as localized scleroderma, is a rare in ammato ry connective tissue disorder. It can also cause muscle pain. Early diagnosis and treatment are essential to minimize morbidity such as joint contracture. occurring primarily in children aged 2–14 years ( 1, 2 ), and in women ( 3 ). Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. 1). Morphea is not the same as scleroderma (systemic sclerosis), and it does not become scleroderma. 1 reference. In this report, we present the case of a 19-year-old man with linear morphea with inflammatory myositis who presented to our clinic 1 year after symptom onset with severe elbow flexion Jan 18, 2023 · Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue disorder with variable clinical presentations, that affects both adults and children. 7 % had craniofacial morphea, 20. The various clinical subtypes of LS require different approaches to evaluation and treatment. When it crosses joints it can cause loss of mobility because of scarring. 1 Systemic sclerosis has an annual incidence of 1 to 2 per 100,000 individuals in the United States. 8 % had linear morphea, and the remainder had either generalized- or plaque-morphea . Jan 8, 2016 · Atrophoderma of Pasini and Pierini is considered an abortive variant of morphea. joint pain. Jun 5, 2016 · The prevalence rates of diseases that share scleroderma as a clinical feature are reported ranging from 4 to 253 cases per 1 million individuals. . Sep 14, 2022 · Myositis is a disease that makes your immune system attack your muscles. Most patients with IMNM produce anti-3-hydroxy-3-methylglutaryl coenzyme A reductase or anti-signal-recognition particle autoantibodies. Morphea, also sometimes called “localized scleroderma,” is a rare autoimmune disorder that causes skin thickening, hardening, and color changes. permanent eye damage in children. Recent Findings In myopathies, pathologic muscle shows an increase in echogenicity. It is characterized by inflammation, excessive collagen production, and subsequently limited sclerosis of the skin; however, in some cases, deeper tissues such as subcutaneous fat, fascia, muscles, or bones might also be involved. The presence of hyperplastic lymphoid follicles in the context of the sclerotic bands of morphea is rarely described. Muscle echogenicity can be assessed visually, semi-quantitatively, or quantitatively using grayscale analysis Dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM) belong to the heterogeneous group of the inflammatory myopathies and are characterized by muscle cell infiltrations and specific alterations of the muscle fibers. More specific treatment recommendations for different organ manifestations have been agreed upon by a consensus conference of international scleroderma experts and were published in 2009 [ 29 ]. Diagnosis. Although the cause of morphea remains poorly investigated, genetic predisposition, immune dysregulation, and environmental factors have been implicated. Jan 10, 2022 · Morphea is an inflammatory disorder characterized by sclerosis of the dermis and subcutaneous fat. IMNM is much rarer in children than in adults. 6 for a full discussion of SSc. Jan 3, 2022 · Linear morphea is the most common presentation in children and associated with increased morbidity. While the pathophysiology of cutaneous linear scleroderma includes endothelial cell injury and up regulation of pro-fibrogenic pathways, the Sep 2, 2020 · September 2, 2020. 1%, 291/581) in the cohort. It has a predilection for the extremities, frontal region of the face, and the thorax (Fig. Loss of hair and sweat glands in the area. Jul 15, 2013 · The juvenile idiopathic inflammatory myopathies (JIIM) are systemic autoimmune diseases characterized by skeletal muscle weakness, characteristic rashes, and other systemic features. Only a few cases have been reported with widespread neurogenic atrophy creating a diagnostic dilemma. May 1, 2020 · Description. The annual incidence of JDM in children younger than 16 years ranges from 2. Both fatty involution and muscle inflammation alter the echogenicity of muscle, which limits the ability of ultrasound to differentiate disease activity from disease damage. Linear morphea is the most common subtype of Morphea is an inflammatory, sclerosing skin disorder that can involve the underlying soft tissues. Apr 1, 2023 · The linear subtype of morphea occurs most commonly in children. stated in Jan 1, 2022 · Linear morphea occurs in pediatric patients in 40%–70% cases and is the most frequent form in this age group. Activity in morphea is characterized histologically by an inflammatory dermal and subcutaneous lymphocytic infiltrate manifesting clinically as erythema, edema, and lesion extension, with patients reporting symptoms such as pain and pruritis (). 001). 8 - other forms of systemic sclerosis. The fourth biopsy, however, was in keeping with LIL given the small yet variable-sized adipocytes with no significant inflammatory infiltrate and only subtle dermal sclerosis Jul 7, 2017 · Morphea with deep lesions, lesions on your face or neck, or widespread lesions can lead to: restricted joint mobility. It can involve the skin, subcutaneous tissue, underlying muscles as well as bone leading to atrophy of the affected part along with deformed growth in children. The female:male ratio was 1. Affected patients present with single or multiple inflammatory and sclerotic plaques, findings considered manifestations of active disease. In this type, plaques develop in a linear pattern, eventually coalescing into a single band of scarring that can extend the length of a limb. In this case, we describe an unusual presentation of a young woman with a rash typical of morphoea (confirmed on biopsy), who went on to develop myositis in an atypical distribution. 41 Genetic mosaicism has been suggested as a contributing Mar 5, 2024 · Morphea, also known as localized scleroderma, is an idiopathic inflammatory disorder that causes sclerotic changes in the skin. It is caused by the accumulation of collagen (a structural protein) in the inner walls of the small arteries that Aug 7, 2023 · Muscle echogenicity is altered in cases of inflammatory myopathy, but these changes are difficult to quantify with respect to extent and severity [2, 3]. Nov 20, 2021 · The histology of morphea depends on the stage and depth of the disease’s extension. Feb 1, 2011 · Linear morphea is reported as the most common subtype in children, affecting 41. Although the association of myositis with diffuse systemic sclerosis is well described, the link with localised scleroderma (morphoea) and myositis has Jul 1, 2018 · This review summarizes the available data on morphhea treatment and provides therapeutic strategies based on morphea subtypes and focuses on randomized controlled trials, prospective interventional trials without controls and retrospective reviews with greater than five subjects. 1–5,17–23 Its prevalence, which was initially estimated in the Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Completed, awaiting results; Primary outcome measures. Early diagnosis and treatment OBJECTIVE. Follow‐up ranged between 10 months and 22 years (mean 6. In this case, we describe an unusual Corticosteroids for myositis, arthritis and other inflammatory clinical features must be used with caution as they can prompt scleroderma renal crisis. Adult May 15, 2020 · Common symptoms of morphea. It is also known as localised scleroderma. The skin is typically the only organ impacted in localized scleroderma. These lesions present as a band or line of induration or atrophy that involves the dermis, subcutaneous tissue, muscle and Apr 25, 2021 · Juvenile dermatomyositis (JDM) is the primary form of JIIM, making up about 80% of cases. Imaging features of morphea are not specific and usually overlap with those of other disorders involving the skin, fascia, and musculature, such as some types of fasciitis, myositis, and so forth. Preferential sites are the abdomen, trunk, sacral area, or extremities. After the inflammatory phase, extensive sclerosis and hyalinization extend into the underlying fascia. AJR Am J Roentgenol 2008;190(1):32–39. Jan 1, 2011 · Inflammatory myopathy is rare in localized scleroderma. 7 If biopsies were performed off site by the referring provider, these slides were obtained and examined in the same manner as specimens obtained by the principal investigator. 9:1, and the mean age at the onset of scleroderma was 5 years and 6 months (range 2 months–14. Furthermore, skin changes in morphea profunda differ from those seen in Jan 1, 2001 · Hemiatrophy caused by linear scleroderma is a race clinical entity of unknown etiology. ) Jul 28, 2020 · Morphea, also known as localized scleroderma, is an idiopathic inflammatory disorder that causes sclerotic changes in the skin. Localized scleroderma skin lesions can get better or even go away. The most frequent complications of morphea include arthralgias, uveitis, and joint contractures, especially in the linear and deep forms1. Linear scleroderma is the most common subtype in JLS, reported in 50–65% [4, 8]. However, in about 32% of cases, it may arise in adulthood, showing a more aggressive course with also an increased risk of systemic involvement. However, the clinical presentation, absence of preceding inflammation, induration, or scleroderma and absence of dermal sclerosis on histopathologic examination, led to a diagnosis of LAM. Regional Ischemic Immune Myopathy (RIIM): Common association with neoplasms. While it shares histopathological characteristics with systemic sclerosis (SSc), it is a distinct entity with a generally better prognosis. OBJECTIVE. 10 Epidemiologic studies report that 5% to 25% of children with Systemic sclerosis (scleroderma) is the most common overlapping disease with myositis. Methotrexate is recommended for linear, deep and generalized morphea. These plaques eventually resolve, leaving permanent dermal or soft tissue Mar 13, 2019 · Morphea may present at any age. 2%). Depending on the clinical features, LSc is classified as (a) linear scleroderma; (b) circumscribed Dec 2, 2019 · This website requires cookies, and the limited processing of your personal data in order to function. Nov 1, 2017 · In this report, we present the case of a 19-year-old man with linear morphea with inflammatory myositis who presented to our clinic 1 year after symptom onset with severe elbow flexion contracture. Dec 1, 2019 · Request PDF | Linear Morphea With Inflammatory Myositis | Morphea is an autoimmune disorder characterized by sclerosis and inflammation of the skin and soft tissues. Morphea is associated with cosmetic and functional sequelae, and internal organ Dec 18, 2020 · The most common is linear scleroderma, followed by plaque and generalized morphea. Linear Morphea is also known as Linear Scleroderma . However, the tissue injury may extend into the structures underlying the skin, including the subcutaneous tissue, fascia, muscle or bone. During the course of the disease, even the underlying muscles, tendons Feb 13, 2021 · Purpose of review Localized scleroderma (LS), also known as morphea, is a complex and poorly understood disorder in children. Eventually, this inflammation makes your muscles feel increasingly weak. 10 participants between the ages of 6 and 18 with morphea plaques. 76), and Parry Apr 24, 2024 · Morphea, also called localized scleroderma, is a chronic autoimmune disease characterized by inflammation and sclerosis of the skin. Morphoea (American spelling, morphea) is characterised by an area of inflammation and fibrosis (thickening and hardening) of the skin due to increased collagen deposition. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody Oct 20, 2011 · An unusual presentation of a young woman with a rash typical of morphoea who went on to develop myositis in an atypical distribution is described. @article{Morris2019LinearMW, title={Linear Morphea With Inflammatory Myositis. In children, the linear subtype predominates while in adults’ plaque and generalized subtypes are most common. Sep 30, 2021 · The specific cause of morphea isn't known. In our patient, the initial clinical diagnosis was linear morphea. 6%, 55/192) than those without (11. We present a patient with an inflammatory myopathy in hemiatrophy resulting from linear scleroderma. Eosinophilic fasciitis (EF, Shulman syndrome) is often Jun 9, 2023 · Morphea is clinically divided into linear, circumscribed (plaque), generalized, pansclerotic, and mixed forms. Myositis is a type of myopathy. Coping. 28 to 3. Our objective was to describe the spectrum of MRI features in patients with deep and generalized morphea. 12. 2 - systemic sclerosis induced by drug and chemical. Nevertheless, the imaging features of morphea reflect pathomorphologic Dec 2, 2019 · Morphea is an autoimmune disorder characterized by sclerosis and inflammation of the skin and soft tissues. 1 - CREST syndrome. Morphea, also known as localized scleroderma (LoS), encompasses a spectrum of autoimmune cutaneous connective tissue diseases. Sep 1, 2011 · Linear scleroderma with orbital involvement: follow up and magnetic resonance imaging. Mar 16, 2017 · Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. Within the linear forms, there are two particular variants that affect the head, namely, linear morphea en coup de sabre, which appears as a linear indurated plaque that involves the dermis of the face and the scalp (Fig. Nevertheless, the imaging features of morphea reflect pathomorphologic Dec 30, 2017 · Localised scleroderma is an uncommon connective tissue disease of multifactorial aetiology occurring in the paediatric and adult population. 0-mm punch biopsies were performed at the erythematous border in inflammatory lesions, or central sclerosis of lesions without clinical inflammation (Fig 1). Next, linear morphea participants were examined in depth over a 3-year period. Crossref, Medline, Google Scholar; 14 Horger M, Fierlbeck G, Kuemmerle-Deschner J, et al. Linear morphea, which usually follows Clinical features suggestive of morphea included wrist discomfort in addition to the linear nature of the findings and the initial dermal inflammation seen on biopsy. 32 Linear, pansclerotic, and generalized variants are most frequently associated with extra-cutaneous complications (Table 5). Other subtypes, such as deep and bullous morphea, are very rare ( 8 ) . It is characterized by inflammatory patches and/or bands of thickened skin on the head and neck region, trunk and extremities (4). Juvenile dermatomyositis (JDM) is associated with many distinguishing features including cutaneous calcinosis, vasculitis, and ulcerated lesions. Deep involvement was more common in linear (64. 0 - localized scleroderma (morphea) M34 - systemic sclerosis (scleroderma) M34. MRI findings in deep and generalized morphea (localized scleroderma). Sep 1, 2020 · Morphea activity versus damage. Oct 20, 2011 · Abstract. Br J Ophthalmol 1996;80(10):930–932. Scleroderma is characterized by the appearance of circumscribed or diffuse, hard, smooth, ivory-colored areas that are immobile and give the appearance of hidebound skin ( Andrews’ Diseases of the Skin ). Morphea occurs more frequently in women, especially in adults where female predominance is marked (5:1). the authors found no evidence of systemic sclerosis in this patient and feel that he has an acute linear morphea with myositis and that Mar 16, 2017 · Linear morphea is the most common subtype in childhood-onset morphea (~65%) , but disease onset might occur during adulthood as well [4, 10]. 1 Abstract. 33,34 Morphea lesions have an initial inflammatory stage characterized by erythematous patches or plaques. It is relatively difficult to conduct any research on the subject of this disease entity treatment due to the low number of patients suffering from morphea, a tendency of the disease to remit spontaneously Aug 4, 2022 · Eleven patients (2 of 16 with plaque morphea, 6 of 33 with linear morphea, and 3 of 4 with generalized morphea) had inflammatory arthritis, which most commonly affected the hands (10 of 11 patients) and was unrelated to the site of cutaneous involvement. }, author={Mark S. 81 - systemic sclerosis with lung involvement. Linear morphea of the limbs and trunk is characterized by a chronic disease course, as the disease may remain active after many decennia [ 26 , 27 ] and recurrences are reported in a large proportion of Morphea profunda may thus present as a neuromuscular mimic, even in case of nonprogressive skin sclerosis. Early diagnosis and treatment are Linear Morphea With Inflammatory Myositis. In DM it is evident a perifascicular atrophy of muscle tissue due to the activation and deposition of complement on capillaries; in PM and IBM there is a Methods: Characteristics of linear morphea versus other subtypes were compared in a cross-sectional manner. Linear morphea often involves deeper structures, including muscle May 16, 2019 · Linear scleroderma “en coup de sabre” (LSES) variant is a cephalic subtype of localized scleroderma that can be associated with extracutaneous stigmata, such as epilepsy, dementia syndromes, as well as focal central nervous system neurologic deficits. The spectrum ranges from relatively mild phenotypes, which generally cause few problems besides local discomfort and visible disfigurement, to subtypes with severe complications such as joint contractures and limb length discrepancies. Through reviewing this rare disorder, it is hoped that early diagnosis will lead to better outcomes in the future. It causes chronic inflammation — swelling that comes and goes over a long time. 3 years). ICD-10: L94. It is thought to be a type of autoimmune disorder, in which the body's immune system mistakenly attacks healthy tissue, causing inflammation and leading to symptoms. Myositis in morphea profunda is generally limited to one region, whereas inflammatory myopathies generally cause diffuse proximal muscle weakness and atrophy. Morris and George R Nov 1, 2022 · Background: Juvenile dermatomyositis is the most common inflammatory myopathy in the pediatric age group and a major cause of mortality and morbidity in individuals with childhood rheumatic diseases. Hardening or thickening of the skin in the area. Possible triggers for morphea can include radiation, skin trauma or a recent infection. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. May 1, 2014 · Histopathology often showed perimysial inflammation and plasma cell infiltration. Failure to recognize and appropriately treat the affected skin and underlying deep connective tissue can lead to long-term morbidity. 1%, 11/99, P < . . 8% to 67% of those children studied. 2%) had a significant ocular involvement and their clinical characteristics are summarised in tables 1 and 2. Although the association of myositis with diffuse systemic Linear morphea occurs in a line usually on the head, arm or leg. Irritated skin may be limited to a single patch or to several patches covering a smaller area. April 2009; Journal of To describe a form of inflammatory myopathy with prominent involvement of the Jan 7, 2022 · Linear morphea is the most common variant in childhood and adolescence. The sclerosis is localized to the dermis but often has a protracted course and is the most common type in childhood-onset morphea. Linear Morphea With Inflammatory Myositis, The Journal of Nov 30, 2019 · The five JLS subtypes are linear scleroderma, circumscribed morphea, generalized morphea, pansclerotic morphea and mixed morphea . Results: Linear morphea was the most common morphea subtype (50. 3%, 187/291) than Jan 1, 2009 · Localized scleroderma, or morphea, although limited to the skin and subcutaneous tissue, can produce lesions that cause severe functional and aesthetic defects. The early eosinophilic inflammatory phase shows the presence of denser, homogenized collagen. Tuffanelli and Winkelmann classified localized scleroderma into the following three categories, which are commonly used today: morphea, linear morphea, and generalized morphea . 7 %), and anterior segment inflammation, including anterior uveitis, also was May 2, 2007 · Twenty‐four patients (3. Feb 13, 2023 · Linear morphea often occurs as a single unilateral lesion on the extremities (Figure 2E) or face and scalp, and it often follows the lines of Blaschko . These plaques eventually become inactive, leaving permanent dermal or soft Nov 1, 2012 · In this report, we present the case of a 19-year-old man with linear morphea with inflammatory myositis who presented to our clinic 1 year after symptom onset with severe elbow flexion contracture. CONCLUSION. Linear morphea en coupe de sabre (LM) usually arises in childhood. Morphea, also known as localized scleroderma, is a rare inflammatory connective tissue disorder occurring primarily in children aged 2–14 years (1, 2), and in women (3). There are many forms, which Linear Morphea is one…which often Jul 17, 2021 · NCT00147771) Nonrandomized, single group open‐label trial, Phase 3, 48‐week. Treatment. Although the association of myositis with diffuse systemic sclerosis is well described, the link with localised scleroderma (morphoea) and myositis has These cases demonstrate that inflammatory myopathy should be considered in patients with localized scleroderma and regional muscle weakness, pain or atrophy. Jan 10, 2022 · Morphea profunda or subcutaneous (deep) morphea is a variant of localized morphea, characterized by one or more ill-defined, deep sclerotic plaque. scientific article published on 02 December 2019. Apr 1, 2009 · Unexplained muscle atrophy as the unique preceding symptom of bilateral linear morphea. En coup de sabre is a characteristic location of linear scleroderma affecting the head and face, but underlying structures including the skull, eyes, and central nervous system may be also Apr 30, 2015 · Inclusion-body myositis is the most common and disabling inflammatory myopathy among persons 50 years of age or older. Over time, the May 1, 2014 · Localized scleroderma (LSc) is an idiopathic inflammatory disorder associated with thickening of the skin and subcutaneous tissue in the absence of typical systemic manifestations of systemic sclerosis (SSc), and with better prognosis [1], [2]. 3%, 187/291) than other morphea subtypes. The most common morphea symptoms include: Reddish or purplish discolored skin patches, which may develop a lighter center. Linear morphea participants with deep involvement were more likely to have a limitation in range of motion (28. Aug 7, 2023 · Linear morphea is characterized by the presence of band-like lesions, which usually manifest over the head and neck or the limbs. The term 'scleroderma' covers various types of morphoea and systemic sclerosis . I t Mar 20, 2023 · Immune-mediated necrotizing myopathy (IMNM) is a type of inflammatory myopathy. It is characterized by inflammation and fibrosis of the skin and underlying soft tissue, in certain cases even of the surrounding structures such as fascia, muscle, bone and central nervous system. Eighteen months after bone marrow transplantation, a 22-year-old man developed polymyositis associated with manifestations of chronic GvHD, such as peripheral eosinophilia and localized morphea. These lesions may heal with hyperpigmentation or may cause growth retardation, muscle atrophy and myositis. 17 per million [106 Sep 28, 2020 · Purpose of Review The purpose of this review is to critically discuss the use of ultrasound in the evaluation of muscle disorders with a particular focus on the emerging use in inflammatory myopathies. We conducted this mini review focusing on pediatric IMNM to present current Jun 1, 2019 · Linear morphea was the most common morphea subtype (50. Damage of skeletal muscle in association with graft-versus-host disease (GvHD) has been referenced exceptionally. In follow-up to our study defining the major clinical subgroup phenotypes of JIIM, we compared demographics, clinical features, laboratory measures, and outcomes ity” which includes superficial plaque morphea can be treated with topical mid potent- potent steroids, tacrolimus, calcipotriol or imiquimod in combination with phototherapy. 160 The early inflammatory stage of morphea is often characterized by pink to violaceous patches or thin plaques which then progress to expand Jun 1, 2017 · At the time of enrollment, 4. hair loss Jul 30, 2021 · 1. When involving the scalp and face, linear morphea has been referred to as morphea en coup d’sabre (linear scleroderma can produce a scarred appearance on the face and scalp similar to what might result from the strike of a sword). Nov 16, 2022 · An unusual presentation in a 12‐year‐old girl who had muscle weakness along with linear morphea over the right upper and lower extremities with overlying lichen sclerosus and calcinosis cutis is described. Other Jan 8, 2021 · Linear Morphea. Immune myopathies with Perimysial pathology (IMPP): 50% of adult Dermatomyositis. Subtypes of morphoea vary according to the Generalized morphea and deep morphea are characterized by sclerosis in the septal portions of the subcutaneous fatty tissue and the deeper layers of the dermis (Fig. cosmetic deformities. Methotrexate is continued for at least 12 months Linear morphea of the limb primarily affects children, and extracutaneous manifestations are common. gm bq ac hj xw ho up cq ah xb