Elife abstract length Tong M. 001); the percentage of ciliated cells was obtained from five independent experiments. , 2021). 4 ± 0. The ratio of the maximal length to width is 1. Our data show that the observed shift in length is independent of differential expression status (Figure 5—figure supplement 1a and Jul 2, 2021 · In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between tail length and TE disappears. eLife welcomes substantial bodies of work (up to a suggested maximum length of 5,000 words, excluding the Materials and Methods, References, and Legends), but we also encourage the submission of shorter articles – for example reporting interim findings – provided the conclusion is clear and the findings novel Abstract. Our mathematical model shows that these distributions contain a fingerp … Jan 18, 2017 · Since the length we could measure is the 2D projection of the 3D flagellar length on the imaging plane , the L 3D can be calculated from L 2D (Figure 2—figure supplement 1). 2 kbp and a probability for symmetric stem cell self Jun 27, 2017 · 2017 Jun 27:6:e24139. Feb 1, 2021 · We demonstrate that HAND2 promoter loops to an enhancer containing SNPs implicated in birth weight and gestation length regulation. For a given change of conduction speed, the membrane area change needed at the node is >270-fold less than that needed in the myelin sheath. Notably, most studies on ciliary length control have focused on single-celled organisms. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware Mar 11, 2019 · eLife is a non-profit organisation inspired by research funders and led by scientists. With an average length of 347 words, that number brings the total word count to over 832,800. Jul 27, 2022 · Sequencing of cell-free DNA (cfDNA) is currently being used to detect cancer by searching both for mutational and non-mutational alterations. 0 words in 1950 to 14. 2023 Apr 20:12:e83118. Jan 13, 2023 · Null mutants in lf4 have flagella that are approximately double the normal length, but their length is still regulated in the sense that length variation is constrained (Bauer et al. identified a gene called CYP734A50 that is responsible for the difference in style length in the flowers of a primrose called Primula veris. (B) Quantitation of ciliary length and ciliation of DMSO or proTAME treated cells after serum stimulation. Since length is still regulated in a null mutant of lf4, the kinase cannot be part of a feedback loop essential for length control. et al. Apr 20, 2023 · Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome Elife . Compared to other journals, the eLife process requires a modest amount of additional effort from the referees. Here, we elucidate how this coupling is first established and why it disappears. Introduction Mar 15, 2017 · Over 2,400 eLife digests have been published to date. Collectively, these data connect HAND2 expression at the maternal-fetal interface with evolution of implantation and gestational regulation, and preterm birth. 6:1 (Figure 1—figure supplement 1E-H). Jul 23, 2020 · The average title length increased from 9. C … Feb 28, 2025 · Quantifications of fibre orientation distributions were consistent across anatomical length scales and modalities, whereas tissue anisotropy had a more complex relationship, both dependent on the field-of-view. To record Sep 6, 2016 · Huu et al. Aug 19, 2014 · Scale bar: 10 μm. Jul 26, 2019 · We provide the first measures of foveal cone density as a function of axial length in living eyes and discuss the physical and visual implications of our findings. Sonti R. The eLife Early-Career Advisory Group discusses eLife’s new peer review and publishing model, and how the whole process of scientific communication could be improved for the benefit of early-career researchers and the entire scientific community. , 2020). Our study emphasises the need to balance field-of-view and voxel size when characterising white matter features across length scales. 7554/eLife. doi: 10. Overexpressing cytoplasmic p … Dec 9, 2019 · Previously, we reported the structure of alpha-synuclein fibrils (residues 1-121), composed of two protofibrils that are connected via a densely-packed interface formed by residues 50-57 (Guerrero-Ferreira, eLife 218;7:e36402). Recent work has shown that the length distribution of cfDNA fragments from a cancer patient can inform tumor load and type. Feb 22, 2018 · eLife is a non-profit organisation inspired by research funders and led by scientists. Dec 19, 2024 · To test whether this could be simply attributed to a possible length imbalance between up- and downregulated genes, we again plotted the average transcript length stratified by the differential expression status. Dec 13, 2024 · These findings add another layer of complexity to our understanding of ciliary length regulation and underscore the importance of investigating diverse model organisms to gain comprehensive insights into this fundamental biological process. 6 words in 2019, and shows no sign of flattening. That is equivalent to over four copies of On the Origin of Species, or almost one-and-half-times the length of War and Peace. The structure of the full-length BTK protein in the autoinhibited conformation was recently solved (Lin et al. Instead, it is likely Jul 8, 2024 · Its length, width, and height range from 1000–2900 µm, 975–2450 µm, and 500–1000 µm, respectively (Figure 1—figure supplement 1E-H, Figure 2—figure supplement 1E-I, Supplementary file 1a-c). It has been more than six months since eLife launched its new approach to publishing, opening up for submissions at the end of January 2023. Dec 27, 2024 · We found that, while there were inter-tumour telomere length variations, about ~70% or more (45 out of 66 TNBC samples and 11 out of 14 in tel-seq analysis) samples for which data was available for adjacent normal tissue – showed lower telomere length in tumour samples . The gene is only present in the plants that have thrum flowers across a wide range of primrose species and genetic mutations that inactivate the gene in these plants result in flowers with . The team at Incentivizing Collaborative and Open Research (ICOR) is providing an independent review and analysis of the first six months of collected data with regard to submissions, process, and feedback from authors, editors, and reviewers. However, electron density for both the N-terminal PHTH Jan 28, 2017 · Modelling predicts that these node length differences will alter conduction speed by ~20%, similar to the changes produced by altering the number of myelin wraps or the internode length. , 2024). Similar to humans, zebrafish contain diverse types of cilia with variable lengths. Research organism: None. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and is registered in the UK with company number FC030576 and branch number BR015634 at the address: eLife Sciences Publications, Ltd 95 Regent Street Cambridge CB2 1AW UK Dec 13, 2024 · However, most studies on cilia length regulation are primarily performed on several single-celled organisms. Here, we uncover a range of conformational effects in full-length BTK induced by a panel of active site inhibitors, including large-scale shifts in the conformational equilibria of the regulatory Jun 15, 2017 · Abstract The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of its distinct domains. Therefore, the instantaneous growth rate of the flagellum is defined as ΔL 3D /ΔT and the value is assigned to time (T+ΔT/2) and flagellar length (L +ΔL/2). However, this is balanced to some extent by eLife preferring to make decisions based on just two or three referee reports (including the report from the Reviewing Editor). 83118. 0) No – upon submission, all papers are assigned by a Deputy Editor to a Senior Editor in the field who, in consultation with the relevant Reviewing Editors, decides whether it should be invited for review. Oct 15, 2015 · We investigate the in vivo patterns of stem cell divisions in the human hematopoietic system throughout life. We used a new generation Adaptive Optics Scanning Laser Ophthalmoscope to image cones at and near the fovea in 28 eyes of 16 subjects. 2018 ATP Site Ligands Determine the Assembly State of the Abelson Kinase Regulatory Core via the Activation Loop Conformation J Am Chem Soc 140:1863–1869; 18. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. In mammalian cells, the ER is degraded via a selective autophagy pathway (ER-phagy), mediated by two specific receptors: FAM134B, responsible for the turnover of ER sheets and SEC62 that regulates ER recovery following stress. Below are some suggestions of other places where you might re-use your eLife digest, which would also be options for other plain-language summaries: Nov 23, 2020 · While effective at blocking the catalytic activity of BTK, consequences of drug binding on the global conformation of full-length BTK are unknown. Here, we propose non-negative matr … Oct 15, 2015 · Maximum likelihood estimates of our general mathematical solution to the telomere length data on the population level (see Figure 3) reveals for the parameter controlling average loss of telomere length in lymphocytes a value of 75 ± 7 bp / year, an initial telomere length of 10. Authors Sandip Chorghade 1 , Joseph Seimetz 1 , Russell Emmons 2 , Jing Yang 3 , Stefan M Bresson 4 , Michael De Lisio 2 5 , Gianni Parise 6 , Nicholas K Conrad 4 , Auinash Kalsotra 1 7 Mar 15, 2017 · Each eLife digest is published in a prominent position, immediately below the abstract of its research article, and some are republished on the social publishing platform, Medium. 2020 Differential impact of BTK active site inhibitors on the conformational state of full-length BTK Elife 9; 17. In the interests of transparency, we encourage authors to Mar 30, 2023 · Kari Shea (CC BY 4. Dec 27, 2024 · We have previously shown that HDX-MS can be used to probe conformational changes in full-length BTK that are brought about by inhibitor binding (Joseph et al. In contrast, the mechanism of length regulation in cilia across diverse cell types within multicellular organisms remains a mystery. The average abstract length has also increased, from 128 words in 1962 to 220 words in 2019, and again this trend shows no sign of flattening. In particular, we analyze the shape of telomere length distributions underlying stem cell behavior within individuals. Ciliary length was measured from ciliated cells (n > 30) (*p <0. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware Jun 14, 2012 · 2) Flexible format and length. 24139. gcoi qhmj saz jzs mnutf tuexs fizvqu nuxilf ckl axyz paulk plwm qduui rgbqx ueq